目的探讨良性前列腺增生(BPH)的血供变化及前列腺动脉栓塞术的临床意义。方法对130例BPH 患者进行经直肠超声前列腺检查,测量前列腺大小,以估算出的重量为标准将130例患者分为4组：≤25 g,26~50 g,51~75 g,≥76 g。测量4组患者尿道前列腺动脉的内径(AD)、最大血流速度(Vmax)、脉动指数(PI)、阻力指数(RI)。130例患者中27例行前列腺动脉栓塞术,比较栓塞前后患者上述测量指标的变化。结果尿道前列腺 AD、Vmax、PI、RI等参数比较,4组患者组内、组间差异均有统计学意义(P <0.05),且尿道前列腺 AD、Vmax、PI、RI等指标与前列腺重量呈正相关。行前列腺动脉栓塞后,尿道前列腺 AD、Vmax、PI、RI及前列腺重量等指标均明显变小,差异有统计学意义(P<0.05)。结论增生前列腺的血液供应明显增加,尿道前列腺动脉血流速度增快,内径增宽,血管阻力增大。阻断尿道前列腺动脉能使增生前列腺组织的血供明显减少,可使前列腺体积缩小,有助于缓解下尿路梗阻。

Objective]To explore the change of blood supply of benign prostatic hyperplasia(BPH)and the significance of arterial embolism of prostate.[Methods]Totally 130 patients with BPH received transrectal ultra-sound of prostate.The size of prostate was measured.According to the estimated weight,all patients were divided into ≤ 25g group,26~50g group,51~75g group and ≥ 76g group.Inner diameter of urethral and prostatic ar-tery,the velocity of maximum flow(Vmax),pulsatility index(PI)and resistance index(RI)in 4 groups were meas-ured.Among 130 patients,27 patients underwent arterial embolism.The changes of the above indexes before and after embolism were compared.[Results]There were significant differences in the inner diameter of urethral and prostatic artery,Vmax,PI and RI among 4 groups(P <0.05).Inner diameter of urethral and prostatic artery, Vmax,PI and RI were positively correlated with the weight of prostate.After arterial embolism,inner diameter of urethral and prostatic art

目的探讨扩散加权成像(DWI)在前列腺外周带癌诊断中的价值。方法分别对21例前列腺癌患者、28例前列腺增生(BPH)患者和15名健康志愿者进行前列腺DWI扫描,分析三者的DWI图、表观扩散系数(ADC)图的信号表现,测量癌灶、前列腺增生、正常前列腺外周带的ADC值。所有前列腺癌及前列腺增生病例均以手术或穿刺活检病理诊断为标准。结果 DWI上前列腺癌灶表现为高信号影,前列腺增生结节呈稍高信号且信号较混杂,正常前列腺外周带呈稍低信号。前列腺癌灶平均ADC值0.98×10~(-3)mm~2/s,前列腺增生结节平均ADC值1.32×10~(-3)mm~2/s;志愿者前列腺外周带平均ADC值2.14×10~(-3)mm~2/s。结论前列腺癌灶、前列腺增生结节、正常前列腺外周带在DWI图像上信号有较大差别,前列腺癌灶信号较高。前列腺癌灶的ADC值低于正常前列腺外周带及前列腺增生结节。DWI是诊断前列腺外周带癌的依据之一。

Objective To explore the diagnostic value of diffusion-weighted imaging(DWI)and apparent diffusion coefficient (ADC)in prostate carcinoma(PCa).Methods Forty-nine patients with histologically confirmed PCa(21)or benign prostatic hyperplasia(BPH,28)and 15 healthy volunteers underwent DWI.The DWI and ADC characteristics were analyzed.Results PCa showed very high signal intensity on DWI.The signal intensity of BPH was more heterogeneous and lower than whereas the signal intensity of normal peripheral zone was even lower and homogeneous.The mean ADC values of PCa,BPH and normal peripheral zone were 0.98×10-3mm2/s,1.32×10-3mm2/s and 2.14×10-3mm2/s,respectively.Conclusions PCa has very high DWI signal intensity with significantly lower ADC values than BPH and normal peripheral zone allowing diagnosis of carcinoma.

目的：观察良性前列腺增生（BPH）合并前列腺炎症与前列腺液、前列腺组织中炎症因子白介素-8（IL-8）、环氧化酶-2（COX-2）水平的相关性。方法80例BPH拟行经尿道前列腺电切术（TURP）患者，根据术后病理学诊断分为单纯性增生组（30例）和增生伴炎症组（50例），两组均于术前进行前列腺液IL-8、COX-2含量测定，术后前列腺组织IL-8、COX-2含量测定，进行统计学分析。结果分别对前列腺液、前列腺组织中IL-8和COX-2 OD值进行组间比较，组间差异性具统计学意义（P＜0.01）；组内比较IL-8和COX-2在前列腺液及前列腺组织中的水平变化，趋势呈线性正相关（r＞0.5），其中，IL-8表达水平在两种标本中呈高度相关（r＞0.08）。结论前列腺液中IL-8、COX-2水平能间接反映前列腺组织中IL-8、COX-2水平，通过检测患者前列腺液中IL-8、COX-2水平可以初步判定BPH患者是否合并有前列腺组织学炎症。

Objective To investigate the relationship between benign prostatic hyperplasia (BPH) with inflammation and level of interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in prostate tissue and expressed prostatic secretions. Methods A total of 80 BPH patients who would be treated by transurethral resection of the prostate (TURP) were divided into simple hyperplasia group (30 patients) and huperplasia with inflammation group (50 patients) identified by postoperative pathologic diagnosis. Preoperative levels of IL-8 and COX-2 in expressed prostatic secretions and postoperative levels of IL-8 and COX-2 in prostate tissue were detected and comparatively analyzed. Results The levels of IL-8 and COX-2 from prostate tissue and expressed prostatic secretions were higher in huperplasia with inflammation group than those in simple hyperplasia group (P 0.05), and IL-8 level in prostate tissue was highly correlated to that of expressed prostatic secretions (r>0.8). Conclusion The levels of IL-8 and CO

目的探讨经会阴前列腺分层饱和穿刺活检在首次前列腺穿刺活检阴性患者中的应用价值。方法 84例因直肠指诊、血清前列腺特异性抗原(PSA)和前列腺MRI检查异常而接受经直肠标准12针穿刺活检且结果为良性的患者,行超声引导下经会阴前列腺分层饱和穿刺活检,计算前列腺癌的检出率。结果 84例患者行经会阴前列腺分层饱和穿刺活检,诊断为前列腺癌23例(27.4%),良性前列腺增生61例(72.6%),其中合并高级别上皮内瘤变3例,慢性前列腺炎5例。结论经会阴前列腺分层饱和穿刺活检可以提高前列腺癌的检出率,对于初次活检阴性,但直肠指诊、前列腺MRI检查异常并且血清前列腺特异性抗原持续升高的患者,可以考虑应用此穿刺活检方法再次穿刺活检予以明确诊断,避免漏诊和延误治疗。

Objective To explore the diagnostic value of transperineal saturation prostate layered biopsy after initial negative biopsy. Methods A total of 84 patients with abnormal rectal examination result and/or elevated prostate specific antigen(PSA) and/or prostate MRI examination result after initial standard 12-core biopsy were enrolled in this study. Using ul-trasound-guided transperineal saturation prostate layered biopsy analysed the detection rate of prostate cancer. Results 84 cases were undertaken ultrasound-guided transperineal saturation prostate layered biopsy, 23 cases (27.4%) of prostate cancer, 61 cases (72.6%) of benign prostate hyperplasia. High grade intraepithelial neoplasia complication were identified in 3 cases (3.6%). Chronic prostatitis complication were identified in 5 cases (5.9%). Conclusion Transperineal saturation prostate layered biop-sy can improve the detection rate of prostate cancer. The patients who are negative after initial biopsy , but are abnormal in rect

探讨前列腺增生患者的血清特异性抗原升高的影响因素。方法:将来我院就诊的170例前列腺增生患者按照血清前列腺特异性抗原(PSA)值分为A、B、C三组,分析患者的年龄、前列腺体积、国际前列腺症状评分(IPSS)、残余尿和前列腺炎与血清PSA之间的关系,并对可能的影响因素做了多元回归性分析。结果:前列腺增生患者的年龄、前列腺体积、IPSS、残余尿和前列腺炎是影响血清PSA的因素,经过多元回归分析显示,年龄、前列腺体积、IPSS和前列腺炎是其独立影响因素。结论:影响血清PSA的危险因素有年龄、前列腺体积、IPSS、残余尿和前列腺炎,其中年龄、前列腺体积、IPSS和前列腺炎是影响血清PSA升高的独立危险因素。

Objective :Elevated serum of patients with benign prostatic hyperplasia specific antigen fac-tors were analyzed .Methods :Our hospital 170 cases of patients with benign prostatic hyperplasia in the future in ac-cordance with the serum prostate-specific antigen (PSA) value was divided into three groups A ,B ,C ,analysis of the patient''s age ,prostate volume ,IPSS ,residual urine and prostatitis serum PSA relationship ,and the possible effects of factors do multiple regression analysis .Results :Prostatic hyperplasia patients age ,prostate volume ,IPSS , residual urine and prostatitis influence factors of the serum PSA after multiple regression analysis showed that age , prostate volume ,IPSS and prostatitis independent impact factors .Conclusion:Affect serum PSA ,age ,prostate vol-ume ,IPSS ,residual urine and prostatitis risk factors ,including age ,prostate volume ,IPSS and prostatitis is an in-dependent risk factor for elevated serum PSA .